Immunohistochemistry of Voltage-Gated Calcium Channel alpha1B Subunit in Mouse Cerebellum.
- Author:
Seung Hyuk CHUNG
1
;
Kyung Youl LEE
;
Ki Hyung KIM
;
Chul Tae KIM
;
Nam Seob LEE
;
Kazuhiko SAWADA
;
Hiromi HAGA
;
Byung Chul LEE
;
Yoshihiro FUKUI
;
Man Hee RHEE
;
Young Gil JEONG
Author Information
1. Department of Anatomy, College of Medicine, Konyang University, Nonsan, Chungnam, 320-711, South Korea. ygjeong@kytis.konyang.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
N-type calcium channels;
Purkinje cell;
Cerebellum
- MeSH:
Animals;
Calcium Channels, N-Type/*metabolism;
Cerebellum/cytology/*metabolism;
Dendrites/metabolism;
Immunohistochemistry;
Mice;
Mice, Inbred BALB C;
Purkinje Cells/metabolism
- From:Journal of Veterinary Science
2002;3(3):175-178
- CountryRepublic of Korea
- Language:English
-
Abstract:
Secretion of neurotransmitters is initiated by voltagegated calcium influx through presynaptic, voltage- gated N-type calcium channels. However, little is known about their cellular distribution in the mouse cerebellum. In the cerebellum, alpha1B immunoreactivity is found mainly on the cell bodies of all Purkinje cells. In addition, the immunoreactivity was detected on a subset of Purkinje cell dendrites, clustered to form a parasagittal array of bands. In the anterior lobe vermis, immunoreactive Purkinje cell dendrites form narrow stripes separated by broad bands of unstained dendrites. Moving caudally through the vermis, these stripes become thicker as a larger fraction of the Purkinje cell dendrites become immunoreactive. This localization study of the alpha1B pore-forming subunits in mouse cerebellum may guide future investigations of the role of calcium channels in neurological pathways.
