Clinical Review of Positive Antinuclear Antibody(ANA) Test in Pediatric Patients.
- Author:
Dong Jin CHOI
;
Kye Sik SHIM
;
Hyeok CHOI
;
Byoung Soo CHO
;
Sung Ho CHA
;
Jin Tae SUH
- Publication Type:Original Article
- MeSH:
Autoimmune Diseases;
Connective Tissue Diseases;
Diagnosis;
Humans;
Immune System Diseases;
Lupus Erythematosus, Systemic;
Pediatrics;
Retrospective Studies
- From:Journal of the Korean Pediatric Society
1994;37(10):1397-1404
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The antinuclear antbody (ANA) test have been used to screen the patients with systemic lupus erythematosus (SLE) and other autoimmune diseases. We had retrospectively reviewed the 263 records of pediatric patients with doing ANA tests who admitted at Department of Pediatrics, Kyung Hee University Hospital, from January 1988 to May 1993. The following results were obtained. 1) The positive rate of ANA test in patients with connective tissue diseases is 16 out of 40(40%).In patients with SLE, the positive rate of ANA test is 9 out of 11 (82%). 2) The positive predictivity for SLE is 9 out 36 (25%). 3) The positive predictivity for connective tissue disease and possible immune disease is 28 out of 36 (78%). 4) The false positive rate is 8 0ut of 36 (22%), Thus, the pediatric patients with positive ANA test should be applicable for diagnosis with prudence. 5) The positive anti-dsDNA in patients with the positive ANA is shown in 4 cases and these patients are all SLE. In conclusion, the patients who had repeated positive ANA should be tested Anti-dsDNA antibody, and further clinical and diagnostic evaluation of other ANA associated diseases.
