A Case of Crescentic Glomerulonephritis with Coexisting Anti-Glomerular Basement Membrane Antibodies and Myeloperoxidase-Anti-Neutrophil Cytoplasmic Autoantibodies.
- Author:
Kyong Yeun JUNG
1
;
Jai Hyang GO
;
Jong Tae CHO
Author Information
1. Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea. jtcho@dankook.ac.kr
- Publication Type:Case Report
- Keywords:
Anti-glomerular basement membrane antibody;
Glomerulonephritis;
ANCA
- MeSH:
Aged;
Anemia;
Antibodies;
Antibodies, Antineutrophil Cytoplasmic;
Autoantibodies;
Basement Membrane;
Cytoplasm;
Female;
Glomerulonephritis;
Hematuria;
Humans;
Immune System Diseases;
Korea;
Proteinuria;
Renal Insufficiency
- From:Korean Journal of Medicine
2012;83(5):654-658
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome involving abrupt or insidious onset of hematuria, proteinuria, and anemia, and rapidly progressive renal failure. Crescentic glomerulonephritis is a histopathological term for RPGN showing extensive extracapillary proliferation, i.e., crescent formation. There are three major immunopathological categories of crescentic glomerulonephritis: anti-glomerular basement membrane (anti-GBM) antibody disease, immune complex-mediated, and pauci-immune (anti-neutrophil cytoplasmic autoantibody [ANCA]-positive). A small minority of all patients with glomerulonephritis develop crescentic glomerulonephritis. Anti-GBM antibodies and ANCA rarely coexist. There have been a few reports of dual positive crescentic glomerulonephritis with anti-GBM antibodies and ANCA in Korea. Here, we describe the case of a 73-year-old woman showing RPGN clinically and crescentic glomerulonephritis pathologically with coexisting anti-GBM antibodies and myeloperoxidase-ANCA.
