A Case of Miller Fisher Syndrome in a Patient with Systemic Lupus Erythematosus.
- Author:
Yong Kang LEE
1
;
Yoon Hye PARK
;
Ara CHOI
;
Chan Hee LEE
;
Jeong Hee CHO
;
Hye Young KIM
;
Pyeong Ho YOON
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Anti-GQ1b antibody;
Miller Fisher syndrome;
Systemic lupus erythematosus
- MeSH:
Diagnosis, Differential;
Diplopia;
Gait;
Humans;
Immunization, Passive;
Incidence;
Korea;
Lupus Erythematosus, Systemic;
Middle Aged;
Miller Fisher Syndrome;
Respiratory Tract Infections
- From:Korean Journal of Medicine
2012;83(5):683-687
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Neuropsychiatric events are common in patients with systemic lupus erythematosus (SLE). The estimated incidence of neuropsychiatric SLE (NPSLE) is 30 to 40%. However, NPSLE poses a difficult diagnostic challenge because a variety of conditions should be considered in the differential diagnosis, especially when patients present with uncommon or rare NPSLE features. We herein describe a 49-year-old man with SLE who initially presented with diplopia, ptosis, and gait disturbance that had developed 1 week after an upper respiratory tract infection. He was finally diagnosed with Miller Fisher syndrome (a variant of Guillain-Barre syndrome) according to clinical symptoms, anti-GQ1b antibody positivity, and neurological study results. The patient recovered without sequelae with intravenous immunoglobulin therapy. This is the first report to describe a case of Miller Fisher syndrome that developed in a patient with SLE in Korea and suggests that Miller Fisher syndrome should be included as a differential diagnosis of NPSLE.
