The Relationship Between Ambulatory Arterial Stiffness Index and Blood Pressure Variability in Hypertensive Patients.
10.4070/kcj.2011.41.5.235
- Author:
Hyung Tak LEE
1
;
Young Hyo LIM
;
Bae Keun KIM
;
Kang Won LEE
;
Jae Ung LEE
;
Kyung Soo KIM
;
Soon Gil KIM
;
Jeong Hyun KIM
;
Heon Kil LIM
;
Jinho SHIN
;
Yu Mi KIM
Author Information
1. Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. jhs2003@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Blood pressure;
Blood pressure monitoring, ambulatory;
Autonomic nervous system diseases
- MeSH:
Autonomic Nervous System Diseases;
Blood Pressure;
Blood Pressure Monitoring, Ambulatory;
Heart Rate;
Humans;
Linear Models;
Retrospective Studies;
Vascular Stiffness
- From:Korean Circulation Journal
2011;41(5):235-240
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Ambulatory arterial stiffness index (AASI) is well known as a predictor of cardiovascular mortality in hypertensive patients. Mathematically, AASI reflect the standard deviation (SD) of blood pressure (BP) variation. AASI is measured higher levels in non-dipper than dipper. Thus, AASI has a possibility of not only reflecting arterial stiffness but also BP variability and/or autonomic nervous dysfunction. SUBJECTS AND METHODS: Consecutive data from 418 untreated hypertensive patients were analyzed retrospectively. We examined the association between the 24-hour ambulatory BP monitoring (ABPM) parameters and AASI. RESULTS: AASI had a simple correlation with age (R=0.189, p<0.001), relative wall thickness (RWT) (R=0.115, p=0.019), left ventricular mass index (LVMI) (R=0.192, p<0.001), average systolic BP (SBP) (R=0.232, p<0.001), average pulse pressure (PP) (R=0.363, p<0.001), SD of diastolic BP (DBP) (R=-0.352, p<0.001), SD of PP (R=0.330, p<0.001), SD of heart rate (HR) (R=-0.268, p<0.001), and nocturnal dipping (R=-0.137, p=0.005). In multiple linear regression analysis model including clinical parameters and 24 hour-ABPM parameters, independent predictors of AASI were SD of PP (beta=1.246, p<0.001), SD of DBP (beta=-1.067, p<0.001), SD of SBP (beta=-0.197, p<0.001), and non-dipper (beta=0.054, p=0.033). CONCLUSION: AASI is closely correlated with BP variability. The result of this study shows that AASI is not only a parameter for arterial stiffness, but also a parameter for BP variability.
