Expression of TGF-beta1, TGF-beta Receptor Type II and VEGF in Colorectal Adenomas and Adenocarcinomas.
- Author:
Sang Bum KANG
1
;
Seung Woo LEE
;
Yeon Soo KIM
;
Soon Woo NAM
;
Dong Soo LEE
;
Jin Man KIM
;
Sok Won HAN
;
Kyu Yong CHOI
Author Information
1. Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. drswnam@korea.com
- Publication Type:Original Article
- Keywords:
TGF-beta1;
TGF-beta receptors;
VEGF;
Colorectal adenoma;
Colorectal adenocarcinoma
- MeSH:
Adenocarcinoma*;
Adenoma*;
Carcinogenesis;
Humans;
Immunohistochemistry;
Lymph Nodes;
Neoplasm Metastasis;
Receptors, Transforming Growth Factor beta*;
Transforming Growth Factor beta*;
Transforming Growth Factor beta1*;
Vascular Endothelial Growth Factor A*
- From:Korean Journal of Gastrointestinal Endoscopy
2007;35(5):313-320
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The aim of study was to investigate the expression of TGF-beta, TGF-RII and VEGF determined by immunohistochemical analysis with a comparison of the clinicopathological parameters such as tumor size, grade of dysplasia, lymph node metastasis and Dukes' stage in colorectal adenomas and adenocarcinomas, by use of a tissue microarray method. METHODS: The expression of TGF-beta1, TGF-betaRII, and VEGF was determined by immunohistochemistry in 20 adenomas and 40 adenocarcinomas. Tissue microarrays consisting of 2 mm cores from corresponding blocks were constructed and stained. RESULTS: In adenomas, the staining intensity of TGF-beta, TGF-betaRII and VEGF was increased in a high-grade dysplasia group of patients as compared a with low-grade dysplasia group of patients, respectively. The staining intensity of TGF-betaRII was significantly increased in a high-grade dysplasia group of patients than a low-grade dysplasia group of patients (p =0.021). For the adenocarcinomas, the expression and staining intensity of TGF-beta1, TGF-betaRII and VEGF were increased as compared with the adenomas (p<0.001). However, no significant correlation was observed between the staining intensity of TGF-beta, TGF-betaRII and VEGF and the clinicopathological parameters. CONCLUSIONS: The increased expression of TGF-beta1, TGF-betaRII and VEGF in colorectal adenocarcinoma suggests a role for these proteins in colorectal carcinogenesis. Loss of the growth-inhibitory effect of TGF-beta may commence in the early stage of colorectal carcinogenesis.
