Relation of Anti- to Pro-Inflammatory Cytokine Ratios with Acute Myocardial Infarction.
10.3904/kjim.2010.25.1.44
- Author:
Santanu BISWAS
1
;
Pradip K GHOSHAL
;
Sankar C MANDAL
;
Nripendranath MANDAL
Author Information
1. Division of Molecular Medicine, Bose Institute, p-1/12 CIT Scheme VIIM, Kolkata-700054, India. mandaln@rediffmail.com
- Publication Type:Original Article
- Keywords:
Myocardial infarction, acute;
Cytokines, inflammatory;
ROC curve
- MeSH:
Adult;
Atherosclerosis/blood/epidemiology/immunology;
Female;
Humans;
Interleukin-10/*blood;
Interleukin-6/*blood;
Logistic Models;
Male;
Middle Aged;
Multivariate Analysis;
*Myocardial Infarction/blood/epidemiology/immunology;
Predictive Value of Tests;
ROC Curve;
Risk Factors
- From:The Korean Journal of Internal Medicine
2010;25(1):44-50
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Acute myocardial infarction (AMI) is a leading cause of death. Inflammatory processes play an important role in atherosclerosis, which is intimately related to AMI. The aim of this study was to investigate the association between anti-inflammatory and pro-inflammatory cytokines ratios and AMI. METHODS: A total of 90 AMI patients and 90 age-and sex-matched controls were recruited in this study. Plasma cytokines and conventional risk factors were determined by standard methods. RESULTS: Patients with AMI showed increased interleukin (IL)-6 and tumor necrosis factor-alpha levels and lower anti- to pro-inflammatory cytokine ratios as compared with controls. A multivariate logistic regression analysis revealed that IL-10 to IL-6 ratio was independently associated with the occurrence of AMI (odds ratio [OR], 5.39; 95% confidence interval [CI], 2.39 to 12.17; p < 0.0001). In contrast, IL-6 levels were no longer significant in the multivariate model (OR, 1.02; 95% CI, 0.932 to 1.12; p = 0.603). A receiver operating characteristic (ROC) curve analysis indicated that IL-6 levels and IL-10 to IL-6 ratios were a significant predictor of AMI (area under ROC curve, 0.892 and 0.851, respectively). CONCLUSIONS: Our results suggest that the ratio of IL-10 to IL-6 is independently associated with AMI, and reduced levels of this ratio may favor the development of AMI.
