Heterologous corneal endothelial cell transplantation: human corneal endothelial cell transplantation in Lewis rats.
10.3346/jkms.1992.7.4.337
- Author:
Hungwon TCHAH
1
Author Information
1. Department of Ophthalmology Asan Medical Center, College of Medicine, Ulsan University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
heterologous transplantation;
corneal endothelium;
immune rejection reaction
- MeSH:
Animals;
Endothelium, Corneal/cytology/immunology/*transplantation;
Female;
Graft Rejection/*immunology;
Humans;
Major Histocompatibility Complex/immunology;
Rats;
Rats, Inbred Lew;
Transplantation, Heterologous
- From:Journal of Korean Medical Science
1992;7(4):337-342
- CountryRepublic of Korea
- Language:English
-
Abstract:
A heterologous corneal endothelial transplantation was attempted using human endothelial cells and a Lewis rat penetrating keratoplasty model. Cultured human endothelial cells were seeded to a Lewis rat cornea, which was denuded of its endothelium. When grafted into the syngeneic Lewis rat, the graft remained clear for at least five days, and then became opaque and edematous because of immune rejection reaction. In contrast, corneas denuded of their endothelium became opaque and edematous immediately after transplantation. These results demonstrate that transplanted endothelial cells have enough antigens to induce rejection reaction even though they have the functional capacity to deturge the cornea.
