Radionuclide Reporter Gene Imaging.
- Author:
Jung Joon MIN
1
Author Information
1. Department of Nuclear Medicine, Chonnam National University Medical School, Gwangju, Korea. jjminmd@hanmail.net
- Publication Type:Original Article
- Keywords:
Reporter gene;
Imaging
- MeSH:
Gene Expression;
Genes, Reporter*;
Genetic Therapy;
Humans;
Molecular Imaging
- From:Korean Journal of Nuclear Medicine
2004;38(2):143-151
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Recent progress in the development of non-invasive imaging technologies continues to strengthen the role of molecular imaging biological research. These tools have been validated recently in variety of research models, and have been shown to provide continuous quantitative monitoring of the location (s), magnitude, and time-variation of gene expression. This article reviews the principles, characteristics, categories and the use of radionuclide reporter gene imaging technologies as they have been used in imaging cell trafficking, imaging gene therapy, imaging endogenous gene expression and imaging molecular interactions. The studies published to date demonstrate that reporter gene imaging technologies will help to accelerate pre-clinical model validation as well as allow for clinical monitoring of human diseases.
