Clinicopathologic Comparison of Intermediate or High Grade Peripheral T-Cell Lymphoma with Diffuse B-Cell Lymphoma.
- Author:
Kyung Hae JUNG
1
;
In Sook WOO
;
Heung Moon CHANG
;
Dae Seog HEO
;
Yung Jue BANG
;
Chul Woo KIM
;
Seonyang PARK
;
Byoung Kook KIM
;
Noe Kyeong KIM
Author Information
1. Department of Internal Medicine, Seoul National University Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Peripheral T-cell lymphoma;
Diffuse B-cell lymphoma;
Intermediate or high grade;
Survival
- MeSH:
B-Lymphocytes*;
Bone Marrow;
Diagnosis;
Disease-Free Survival;
Gastrointestinal Tract;
Humans;
Immunophenotyping;
Lymphoma, B-Cell*;
Lymphoma, Non-Hodgkin;
Lymphoma, T-Cell, Peripheral*;
Skin;
Survival Rate;
T-Lymphocytes
- From:Journal of the Korean Cancer Association
1997;29(1):136-145
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Peripheral T-cell lymphoma (PTCL) derived from mature T cells forms morphologically diverse group of non-Hodgkin's lymphomas and the clinicopathologic features remain to be debated. In order to elucidate the specific characteristics of PTCL, comparison with a group of diffuse B-cell lymphomas (DBCL) was done. MATERIALS AND METHODS: Between Dec. 1989 and Feb. 1993, clinical data of 67 cases of intermediate or high grade NHL identified as T-cell or B-cell origin by immunophenotyping was reviewed. RESULTS: There were 30 cases of PTCL and 37 cases of DBCL. PTCL had more advanced stage and B symptoms at diagnosis. Frequent sites of extranodal involvement were bone marrow, nasal cavity/paranasal sinus, and skin in PTCL and gastrointestinal tract in DBCL. Based on NCI Working Formulation, 40% of PTCL and 14% of DBCL were high grade. Patients with DBCL had a better 3-year overall survival rate (67% vs 47%), however, there was no difference in complete remission rate and disease-free survival rate between two groups with intensive treatment. A subgroup of PTCL patients who had died earlier was found to have more advanced stage and poor performance status. CONCLUSION: Although patients with PTCL had worse survival in advanced stage, the outcome of patients with PTCL who received intensive treatment was comparable to that of DBCL.