Factors Related to Complications of Childhood Obesity.
- Author:
Jong Gyun AHN
1
;
Jeong Mee KIM
;
Jeh Hoon SHIN
Author Information
1. Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea. hjshin@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Hyperinsulinemia;
Insulin resistance;
Dyslipidemia;
ALT;
Obesity;
Children
- MeSH:
Body Mass Index;
Child;
Cholesterol;
Dyslipidemias;
Fasting;
Fatty Liver;
Glucose;
Humans;
Hyperinsulinism;
Insulin;
Insulin Resistance;
Insulin-Like Growth Factor Binding Protein 3;
Insulin-Like Growth Factor I;
Leptin;
Obesity;
Pediatric Obesity*;
Prevalence;
Triglycerides
- From:Journal of Korean Society of Pediatric Endocrinology
2006;11(1):76-84
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Childhood obesity is associated with complications such as hyperinsulinemia/insulin resistance, dyslipidemia and fatty liver. The aims of this study were to evaluate the difference of measurements between obese and normal weight children and to investigate the factors related to complications of obesity. METHODS: The body mass index (BMI), trunk and total fat percent, lipid profiles, ALT, AST, leptin, LH, FSH, fasting insulin, glucose, IGF-1, IGFBP-3 were measured in 97 children (49 obese children and 48 non-obese controls). We calculated G/I ratio, loginsuin, HOMA-IR, logHOMA-IR, and QUICKI and evaluated the relationship between each anthropometric data and metabolic data. RESULTS: Hyperinsulinemia, dyslipidemia and abnormal ALT showed high prevalence in obese children. In obese, BMI was correlated with G/I ratio (r=-0.309, P<0.05), loginsuin (r=0.381, P<0.05), logHOMA-IR (r= 0.342, P<0.05), QUICKI (r=-0.343, P<0.05), ALT (r=0.451, P<0.01)) and AST (r=0.289, P<0.05). Serum insulin level had positive correlation with BMI (r=0.345, P<0.01), serum triglyceride (r=0.332, P<0.05) and all insulin resistance indices (P<0.01). Serum leptin levels were significantly correlated with BMI (r=0.555, P<0.01), trunk (r=0.463, P<0.01)) and total (r=0.506, P<0.01) fat percent, LDL (r=0.350, P<0.05), total cholesterol (r=0.297, P<0.05). CONCLUSION: BMI is valuable for predicting insulin resistance and prevalence of abnormal ALT or AST. Monitoring of insulin level is helpful to assess the morbidities of obesity. Also, serum leptin level might be an important predictor of obesity.
