Comparative Vestibulotoxicity of Different Aminoglycosides in the Guinea Pigs.
10.3349/ymj.2003.44.3.517
- Author:
Erol SELIMOGLU
1
;
Saadettin KALKANDELEN
;
Fazli ERDOGAN
Author Information
1. Department of Otolaryngology, Ataturk Universitesi, Tip Fakultesi, KBB Hastaliklari AD, 25240, Erzurum, Turkey. erolselimoglu@hotmail.com
- Publication Type:Original Article ; Comparative Study
- Keywords:
Vestibulotoxicity;
aminoglycosides;
streptomycin;
gentamicin;
amikacin;
netilmicin
- MeSH:
Amikacin/administration & dosage/*poisoning;
Animals;
Comparative Study;
Gentamicins/administration & dosage/*poisoning;
Guinea Pigs;
Injections, Intraperitoneal;
Netilmicin/administration & dosage/*poisoning;
Streptomycin/administration & dosage/*poisoning;
Tympanic Membrane;
Vestibule/*drug effects
- From:Yonsei Medical Journal
2003;44(3):517-522
- CountryRepublic of Korea
- Language:English
-
Abstract:
The histopathological alterations in the vestibule due to aminoglycosides are well defined. Although there are reports comparing the vestibulotoxic effects of the many aminoglycosides, this is the first study to compare the effects of the most commonly used aminoglycosides i.e., streptomycin, gentamicin, amikacin and netilmicin administered both transtympanically and systemically. The transtympanic and systemic administration of each aminoglycoside caused similar histopathological alterations in the vestibule. The most severe degeneration in the cristae ampullaris, utriculus and sacculus was observed after streptomycine administration. The severity of the vestibular damage in terms of magnitude was in the order of streptomycine, gentamicin, amikacin, and netilmicin.
