Clinical value of serum vascular endothelial growth factor (VEGF) in ovarian diseases.
- Author:
Joo Hee YOON
1
;
Dae Hoon KIM
;
Young Oak LEW
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea. yolew@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Ovarian disease;
VEGF
- MeSH:
Diagnosis, Differential;
Enzyme-Linked Immunosorbent Assay;
Female;
Healthy Volunteers;
Humans;
Ovarian Diseases*;
Ovarian Neoplasms;
Biomarkers, Tumor;
Vascular Endothelial Growth Factor A*
- From:Korean Journal of Obstetrics and Gynecology
2007;50(1):135-141
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of this study was to evaluate the concentration of serum VEGF and its relationship with the clinical parameters and the tumor markers in ovarian diseases. METHODS: We measured the serum VEGF concentrations by ELISA in 76 patients with benign ovarian disease, as well as 9 normal volunteers, 4 patients with ovarian borderline malignancy and 53 patients with ovarian cancer. RESULTS: There is a significant statistical difference between the serum VEGF levels in patients with benign ovarian disease (157.7+/-197.8 pg/ml) and ovarian cancer (344.7+/-372.2 pg/ml) (p<0.005). CONCLUSION: Serum VEGF may help in the differential diagnosis between benign and malignant ovarian disease. We suggest that serum VEGF may be useful as a diagnostic tool in ovarian disease.
