Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages.
10.3349/ymj.2012.53.3.654
- Author:
Seungjae KIM
1
;
In Hong CHOI
Author Information
1. Department of Microbiology, Brain Korea 21 Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea. inhong@yuhs.ac
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
Silver nanoparticles;
macrophages;
endocytosis;
phagocytosis;
IL-8
- MeSH:
Cell Line;
Cell Survival/drug effects;
Endocytosis/*physiology;
Humans;
Interleukin-8/*metabolism;
Macrophages/drug effects/*metabolism;
Metal Nanoparticles/*chemistry;
Phagocytosis/*physiology;
Silver/*chemistry/pharmacology
- From:Yonsei Medical Journal
2012;53(3):654-657
- CountryRepublic of Korea
- Language:English
-
Abstract:
Phagocytosis or endocytosis by macrophages is critical to the uptake of fine particles, including nanoparticles, in order to initiate toxic effects in cells. Here, our data enhance the understanding of the process of internalization of silver nanoparticles by macrophages. When macrophages were pre-treated with inhibitors to phagocytosis, caveolin-mediated endocytosis, or clathrin-mediated endocytosis, prior to exposure to silver nanoparticles, Interleukin-8 (IL-8) production was inhibited. Although cell death was not reduced, the inflammatory response by macrophages was compromised by phagocytosis and endocytosis inhibitors.
