Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Patient with Large Cell Neuroendocrine Carcinoma.
10.3349/ymj.2012.53.3.667
- Author:
Hyung Jung OH
1
;
Mi Jung LEE
;
Seon Jung JANG
;
Dong Ho SHIN
;
Shin Wook KANG
Author Information
1. Department of Internal Medicine, Division of Nephrology, Yonsei University College of Medicine, Seoul, Korea. kswkidney@yuhs.ac
- Publication Type:Case Reports
- Keywords:
Hyponatremia;
syndrome of inappropriate antidiuresis;
large cell neuroendocrine carcinoma
- MeSH:
Carcinoma, Large Cell/*pathology;
Carcinoma, Neuroendocrine/*pathology;
Humans;
Inappropriate ADH Syndrome/*pathology;
Male;
Middle Aged
- From:Yonsei Medical Journal
2012;53(3):667-669
- CountryRepublic of Korea
- Language:English
-
Abstract:
The syndrome of inappropriate antidiuretic hormone secretion has only been reported in a few patients with large cell neuroendocrine carcinoma (LCNEC); however, it has never been reported in a patient with LCNEC of the lung, whose serum sodium levels were normalized after surgical resection of the mass. A 63-year-old male presented with a two-day history of dizziness and recent memory loss. On admission, his serum sodium level was 113 mEq/L with a serum osmolality of 236 mosm/kg, a urine osmolality of 441 mosm/kg, and a urine sodium level of 65 mEq/L. His chest computed tomography revealed a 2.7x2.3 cm-sized mass in the left lower lobe. After surgical removal of the mass, his serum sodium concentrations were normalized, and histopathology of the mass revealed LCNEC.
