S100A8/A9 as a biomarker for synovial inflammation and joint damage in patients with rheumatoid arthritis.
10.3904/kjim.2014.29.1.12
- Author:
Kwi Young KANG
1
;
Jung Won WOO
;
Sung Hwan PARK
Author Information
1. Division of Rheumatology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. rapark@catholic.ac.kr
- Publication Type:Review ; Research Support, Non-U.S. Gov't
- Keywords:
S100A8;
S100A9;
Arthritis, rheumatoid;
Biological markers
- MeSH:
Arthritis, Rheumatoid/*blood/pathology/radiography;
Arthrography;
Biological Markers/blood;
Calgranulin A/*blood;
Calgranulin B/*blood;
Humans;
Joints/pathology;
Synovial Fluid/metabolism
- From:The Korean Journal of Internal Medicine
2014;29(1):12-19
- CountryRepublic of Korea
- Language:English
-
Abstract:
S100A8 and S100A9 are major leukocyte proteins, known as damage-associated molecular patterns, found at high concentrations in the synovial fluid of patients with rheumatoid arthritis (RA). A heterodimeric complex of S100A8/A9 is secreted by activated leukocytes and binds to Toll-like receptor 4, which mediates downstream signaling and promotes inflammation and autoimmunity. Serum and synovial fluid levels of S100A8/A9 are markedly higher in patients with RA than in patients with osteoarthritis or miscellaneous inflammatory arthritis. Serum levels of S100A8/A9 are significantly correlated with clinical and laboratory markers of inflammation, such as C-reactive protein, erythrocyte sedimentation rate, rheumatoid factor, and the Disease Activity Score for 28 joints. Significant correlations have also been found between S100A8/A9 and radiographic and clinical assessments of joint damage, such as hand radiographs and the Rheumatoid Arthritis Articular Damage score. In addition, among known inflammatory markers, S100A8/A9 has the strongest correlation with total sum scores of ultrasonography assessment. Furthermore, baseline levels of S100A8/A9 are independently associated with progression of joint destruction in longitudinal studies and are responsive to change during conventional and biologic treatments. These findings suggest S100A8/A9 to be a valuable diagnostic and prognostic biomarker for RA.
