The Effect of a Small Dose of Glycopyrrolate (Robinul) on the Heart Rate .
10.4097/kjae.1982.15.1.25
- Author:
Chang Young JEONG
1
;
Cheol Seung LEE
Author Information
1. Department of Anesthesiology, Chonnam University Medical School, Kwangju, Korea.
- Publication Type:Original Article
- MeSH:
Atropine;
Ganglia, Sympathetic;
Glycopyrrolate*;
Healthy Volunteers;
Heart Rate*;
Heart*
- From:Korean Journal of Anesthesiology
1982;15(1):25-31
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this study was to observe in healthy human volunteers the effect of a small dose of glycopyrrolate given intravenously, and to compare its effect with that of atropine. The results are as follows: 1) The usual dose of glycopyrrolate(0.2mg) showed no detectable change in the heart rate. 2) A small dose of glycopyrrolate(0.1mg) showed a decreasing tendency in the heart rate, but it was not a statistically significant decrease. 3) A small dose of glycopyrrolate(0.15mg) showed a significant decrease in the heart rate. 4) A small dose of glycopyrrolate(0.1mg) 10 minutes after glycopyrrolate(0.1mg) showed a significant increase in the heart rate. 5) A small dose of glycopyrrolate(0.15mg) 10 minutes after glycopyrrolate(0.1mg)did not cause a decrease in the heart rate. 6) A small dose of glycopyrrolate(0.1mg) 10 minutes after glycopyrrolate(0.15mg) showed a marked increase in the heart rate. 7) From the above results, it is infered that both glycopyrrolate and atropine have an effect on the sympathetic ganglia.
