Effects of Radiation Therapy on Established Neurogenic Heterotopic Ossification.
10.5535/arm.2016.40.6.1135
- Author:
Chan Ho LEE
1
;
Su Jung SHIM
;
Hyun Jung KIM
;
Hyuna YANG
;
Youn Joo KANG
Author Information
1. Department of Rehabilitation Medicine, Eulji Hospital, Eulji University School of Medicine, Seoul, Korea. md52516@hanmail.net
- Publication Type:Case Report
- Keywords:
Brain injuries;
Heterotopic ossification;
Radiotherapy
- MeSH:
Alkaline Phosphatase;
Amputation;
Brain Injuries;
Extremities;
Humans;
Ossification, Heterotopic*;
Radiotherapy;
Range of Motion, Articular;
Rehabilitation;
Spinal Cord Injuries
- From:Annals of Rehabilitation Medicine
2016;40(6):1135-1139
- CountryRepublic of Korea
- Language:English
-
Abstract:
Heterotopic ossification (HO) is frequently seen on rehabilitation units after spinal cord injuries, fractures, brain injuries, and limb amputations. Currently, there is no effective treatment for HO other than prophylaxis with anti-inflammatory medications, irradiation, and bisphosphonate administration. These prophylactic treatments are not effective for managing ectopic bone once it has formed. Here we describe three cases of established neurogenic HO treated with radiation therapy (RT). All patients had decreased serum alkaline phosphatase (ALP) and bone-specific ALP levels with decreased pain but increased range of motion immediately after RT. Post-treatment X-rays revealed no further growth of the HO. All patients maintained clinical and laboratory improvements 4 or 6 months after the RT. Our results suggest that RT is safe and effective in decreasing pain and activity of neurogenic HO.
