A case of anticonvulsant hypersensitivity syndrome with pseudolymphoma induced by carbamazepine.
- Author:
Sung Jin PARK
1
;
Soon Bock KANG
;
Sang Hoon LEE
;
Do Youg JUNG
;
Ji Hoon YOO
;
Jae Yeol KIM
;
In Won PARK
;
Byoung Whui CHOI
Author Information
1. Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Anticonvulsant hypersensitivity syndrome;
Carbamazepine;
pseudolymphoma
- MeSH:
Biopsy;
Carbamazepine*;
Diagnosis;
Fever;
Hepatitis;
Humans;
Hypersensitivity*;
Lymph Nodes;
Lymphatic Diseases;
Phenobarbital;
Phenytoin;
Pseudolymphoma*;
Skin
- From:Journal of Asthma, Allergy and Clinical Immunology
2001;21(4):657-661
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anticonvulsant hypersensitivity syndrome(AHS) is an uncommon, but potentially fatal, multi-systemic disorder that occurs after exposure to phenytoin, carbamazepine, phenobarbital. Clinical features and laboratory data are diverse and variable. The multi-systemic reaction presents as fever, skin eruptions, lymphadenopathy, hematologic abnormality, and hepatitis. It is postulated that this mechanism can cause deficient enzymatic reduction by epoxide hydrolase. The diagnosis of AHS is made by reviewing the history of drug exposure and clinical course. It is important to discontinue use of the offending drug suspected for AHS and to closely observe patients with anticonvulsant therapy. We experienced a case of anticonvulsant hypersensitivity syndrome developed by carbama-zepine, presented with pseudolymphoma in lymph node biopsy and improved by discontinuing the drug and implementing steroid treatment. We report this case with pathologic findings and a brief review.
