Diffuse Alveolar Hemorrhage Associated with Antineutrophil Cytoplasmic Antibody levels in a Pregnant Woman Taking Propylthiouracil.
10.3904/kjim.2006.21.4.240
- Author:
Ah Young KANG
1
;
Yang Hyun BAEK
;
You Jung SOHN
;
Soo Keol LEE
;
Choon Hee SON
;
KyeongHee KIM
;
Doo Kyung YANG
Author Information
1. Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. imyang1@yahoo.com
- Publication Type:Case Report
- Keywords:
Antineutrophil cytoplasmic antibody;
Propylthiouracil
- MeSH:
Tomography, X-Ray Computed;
*Pulmonary Alveoli;
Propylthiouracil/*adverse effects/therapeutic use;
*Pregnancy Complications, Hematologic;
Pregnancy;
Hyperthyroidism/blood/complications/*drug therapy;
Humans;
Hemoptysis/*chemically induced/diagnosis/immunology;
Female;
Diagnosis, Differential;
Bronchoscopy;
Antithyroid Agents/*adverse effects/therapeutic use;
Antibodies, Antineutrophil Cytoplasmic/*blood;
Adult
- From:The Korean Journal of Internal Medicine
2006;21(4):240-243
- CountryRepublic of Korea
- Language:English
-
Abstract:
Propylthiouracil (PTU) is known to be a potential cause of antineutrophil cytoplasmic antibody (ANCA) positive small vessel vasculitis, resulting in glomerulonephritis and diffuse alveolar hemorrhage (DAH). Herein, we describe a 25-year-old pregnant woman who developed a perinulcear ANCA (p-ANCA) and myeloperoxidase ANCA (MPO-ANCA) positive DAH during PTU therapy. The patient improved after corticosteroid therapy and discontinuation of the PTU. Methimazole was prescribed in spite of the risk of recurrence of DAH because of the pregnancy. The patient is currently free from pulmonary problems. Our case shows that the alternative agent, methimazole, can be used to treat hyperthyroidism in a pregnant patient with PTU associated DAH.
