Capecitabine and Oxaliplatin (XELOX) for the Treatment of Patients with Metastatic Gastric Cancer and Severe Liver Dysfunction.
10.3904/kjim.2006.21.4.252
- Author:
Seung Jae HWANG
1
;
Jong Won PARK
;
Sehe Dong LEE
;
Gyong Jung KIM
;
Cheol Ho SIN
;
Seung Hyun NAM
;
Bong Seog KIM
Author Information
1. Department of Internal Medicine, Seoul Veterans Hospital, Seoul, Korea. seog@e-bohun.or.kr
- Publication Type:Case Report
- Keywords:
Gastric Cancer;
Liver Failure;
Capecitabine;
Oxaliplatin
- MeSH:
Stomach Neoplasms/complications/*pathology/surgery;
Prodrugs;
Organoplatinum Compounds/*therapeutic use;
Middle Aged;
Male;
Liver Neoplasms/complications/*drug therapy/secondary;
Liver Function Tests;
Liver Failure/diagnosis/drug therapy/*etiology;
Humans;
Gastrectomy;
Follow-Up Studies;
Fluorouracil/*analogs & derivatives/therapeutic use;
Drug Therapy, Combination;
Deoxycytidine/*analogs & derivatives/therapeutic use;
Antineoplastic Agents/*therapeutic use;
Adenocarcinoma/complications/secondary/*therapy
- From:The Korean Journal of Internal Medicine
2006;21(4):252-255
- CountryRepublic of Korea
- Language:English
-
Abstract:
Gastric cancer patients with severe liver dysfunction secondary to hepatic metastases have limited treatment options. Most cytotoxic drugs have a narrow therapeutic index. Although both capecitabine and oxaliplatin have been well tolerated as single agents for patients with severe hepatic dysfunction, the combination of these drugs has not been investigated. We report here on a case of successful treatment of a patient suffering with severe liver dysfunction and metastatic gastric cancer; the patient was treated with a combination of capecitabine and oxaliplatin (XELOX). The initial bilirubin level of the patient was 10.9 mg/dL. After two cycles of treatment, his bilirubin level decreased to 2.1 mg/dL. He has experienced an excellent radiological response and he has received six cycles of XELOX chemotherapy. XELOX chemotherapy is feasible and it can be associated with positive outcomes for the patients suffering with metastatic gastric cancer and severe liver dysfunction.
