The Analysis of Treatment of Aggressive Fibromatosis Using Oral Methotrexate Chemotherapy.
10.4055/cios.2014.6.4.439
- Author:
Gi Woon YOON
1
;
Jae Do KIM
;
So Hak CHUNG
Author Information
1. Department of Orthopaedic Surgery, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea. shchung@Kosin.ac.kr
- Publication Type:Original Article
- Keywords:
Aggressive fibromatosis;
Oral methotrexate
- MeSH:
Administration, Oral;
Adolescent;
Adult;
Aged;
Antimetabolites, Antineoplastic/*administration & dosage;
Child;
Female;
Fibromatosis, Aggressive/*drug therapy/surgery;
Humans;
Male;
Methotrexate/*administration & dosage;
Middle Aged;
Neoplasm Recurrence, Local/*drug therapy/surgery;
Retrospective Studies;
Young Adult
- From:Clinics in Orthopedic Surgery
2014;6(4):439-442
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Aggressive fibromatosis is a rare but invasive tumor infiltrating widely between fascia and muscle fibers. It has a high tendency to be locally recurrent despite complete resection. Effectiveness of adjuvant treatment for aggressive fibromatosis including radiotherapy, pharmacological agents, hormonal treatments, and chemotherapy have been previously reported. The purpose of this article was to collect and analyze all information regarding the effectiveness and side effects of oral methotrexate in aggressive fibromatosis. METHODS: From 2005 to 2011, eleven patients with aggressive fibromatosis treated with oral methotrexate at our institution were analyzed in this study. Oral methotrexate was administered once per week at 10 mg per week. Authors collected information about effectiveness concerning cases of local recurrence and metastasis. RESULTS: Eleven patients had remission, two patients had local recurrence. Fatal complications or toxicity were not observed. CONCLUSIONS: Oral methotrexate given at this dose and schedule was considered as a useful treatment in primary inoperable fibromatosis and recurrent fibromatosis.
