A case of acute Q fever with fibrin-ring granuloma in the bone marrow and lymph node biopsy.
- Author:
Oh Hyun CHO
1
;
Young Sill CHOI
;
Tark KIM
;
Ki Ho PARK
;
Ryan OH
;
Hyun Sook CHI
;
Yang Soo KIM
Author Information
1. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. YSKim@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Q fever;
Coxiella burnetii;
Fibrin-ring granuloma
- MeSH:
Biopsy;
Bone Marrow;
Coxiella burnetii;
Diagnosis, Differential;
Fever;
Fever of Unknown Origin;
Granuloma;
Hepatitis;
Humans;
Immunoglobulin G;
Korea;
Lymph Nodes;
Male;
Middle Aged;
Pneumonia;
Polymerase Chain Reaction;
Q Fever
- From:Korean Journal of Medicine
2009;76(Suppl 1):S190-S194
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Q fever is a zoonotic infection caused by Coxiella burnetii. Acute Q fever usually develops as a self-limited flu-like illness, atypical pneumonia, or hepatitis. We experienced a case of Q fever in a 50-year-old male who had a prolonged fever. The bone marrow and lymph node biopsy revealed fibrin-ring granulomas, which is a distinct finding of Q fever. The diagnosis was proven by high titers of C. burnetii anti-phase II antibody (IgM 1:512 and IgG >,048) and positive nested PCR for the com-1 gene. Q fever is rare in Korea, but should be considered in the differential diagnosis of fever of unknown origin
