Acute generalized exanthematous pustulosis due to amoxicillin/clavulanate.
- Author:
Song Mi MOON
1
;
Mi Suk LEE
;
Jun Seong SON
Author Information
1. Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea. sonjs@korea.com
- Publication Type:Case Report
- Keywords:
Acute generalized exanthematous pustulosis;
Pustular drug rash;
Amoxicillin/clavulanate
- MeSH:
Acute Generalized Exanthematous Pustulosis;
Adult;
Anti-Bacterial Agents;
Biopsy;
Female;
Fever;
Humans;
Hypersensitivity;
Leukocytosis;
Neutrophils;
Pharyngitis;
Skin;
Thoracic Wall
- From:Korean Journal of Medicine
2009;76(Suppl 1):S216-S219
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acute generalized exanthematous pustulosis (AGEP) was initially named by Beylot to describe a disease entity with sudden- onset amicrobial pustular eruptions accompanied by fever and leukocytosis. Most cases appear to be related to drug reactions, mainly antibiotics, although viral infections and hypersensitivity to mercury also cause AGEP. A 28-year-old woman presented with sudden-onset, multiple, and generally pinhead-sized pustules on an erythematous base scattered on the face and anterior chest wall. The patient had been on amoxicillin/clavulanate for acute pharyngitis. Histopathologically, the skin biopsy specimen revealed subcorneal and subepidermal pustules with neutrophil spongiosis, perivascular neutrophilic infiltration, and karyorrhectic debris. The eruption cleared rapidly after discontinuing the drug and administering systemic corticosteroid therapy.
