Correlation between Serum Cystatin C Levels and Clinical Parameters in Children with Urinary Tract Infections.
10.3339/jkspn.2014.18.2.85
- Author:
Ji Hyun SIM
1
;
Hyung Eun YIM
;
Kee Hwan YOO
Author Information
1. Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea. he-yim@hanmail.net
- Publication Type:Original Article
- Keywords:
Cystatin C;
Urinary tract infection;
Pyelonephritis
- MeSH:
Child*;
Creatinine;
Cystatin C*;
Humans;
Pyelonephritis;
Radionuclide Imaging;
Reference Values;
Urinary Tract Infections*
- From:Journal of the Korean Society of Pediatric Nephrology
2014;18(2):85-91
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We aimed to investigate the correlation between serum cystatin C and clinical manifestations in pediatric patients with urinary tract infections (UTIs). METHODS: We studied 137 patients admitted with UTIs from June 2012 to May 2014. Depending on the presence of renal cortical defects on 99m Tc-dimercaptosuccinic acid scintigraphy, we classified patients into non-renal and renal defect groups. Laboratory and clinical parameters were analyzed, including the levels of serum cystatin C. The correlation between cystatin C and other variables was assessed. RESULTS: Serum cystatin C levels did not differ between the non-renal and renal defect groups. In both groups, serum cystatin C levels increased after 4-5 days of treatment, compared with the level at admission (P<0.001). However, mean levels were within normal ranges. The concentration of serum cystatin C positively correlated with serum creatinine and negatively correlated with age (P<0.05). In contrast, there was no correlation between serum cystatin C and other variables. CONCLUSION: Serum cystatin C does not appear to be a useful biomarker for renal defects in pediatric patients with UTIs. Further studies are necessary to conclude whether serum cystatin C is helpful in predicting deterioration in renal function in pediatric patients with UTIs.
