High-dose Vitamin C therapy in Methemoglobinemia.
- Author:
Kyung Woo LEE
1
;
Tae Sin KANG
;
Sin Youl PARK
Author Information
1. Department of Emergency Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
- Publication Type:Case Report
- Keywords:
Methemoglobinemia;
Vitamin C;
Dapsone;
Methylene blue
- MeSH:
Aged;
Ascorbic Acid*;
Cyanosis;
Dapsone;
Emergency Service, Hospital;
Female;
Humans;
Methemoglobinemia*;
Methylene Blue;
Renal Insufficiency;
Tablets;
Tachypnea
- From:Journal of the Korean Society of Emergency Medicine
2014;25(2):202-205
- CountryRepublic of Korea
- Language:English
-
Abstract:
Methylene blue is the first choice antidote for management of methemoglobinemia, however, some patients are refractory to methylene blue and in most cases, methylene blue cannot be available instantly in Korean emergency departments because of import suspension. A 69-year-old woman visited our emergency department for tachypnea and cyanosis after ingesting 30 tablets of dapsone. Because methylene blue was not available, we intravenously administrated 10 g of vitamin C for symptomatic methemoglobinemia. Repeated i.v. administrations of 10 g of vitamin C in patient without preexisting renal insufficiency successfully treated dapsone-induced methemoglobinemia without causing renal complications. Thus, we recommend that if methylene blue is unavailable or methemoglobinemia is refractory to methylene blue, repeated administrations of 10 g of vitamin C may be considered for the treatment of methemoglobinemia in patients without renal insufficiency.
