B Cells Promote Th1- Skewed NKT Cell Response by CD1d-TCR Interaction.
- Author:
Jung Hoon SHIN
1
;
Se Ho PARK
Author Information
- Publication Type:Brief Communication
- Keywords: B cells; Dendritic cells; NKT cells; alpha-galactosylceramide and Th1 response
- MeSH: Antigen-Presenting Cells; B-Lymphocytes*; Coculture Techniques; Dendritic Cells; Galactosylceramides; Interleukin-4; Natural Killer T-Cells*
- From:Immune Network 2013;13(5):218-221
- CountryRepublic of Korea
- Language:English
- Abstract: CD1d expressing dendritic cells (DCs) are good glyco-lipid antigen presenting cells for NKT cells. However, resting B cells are very weak stimulators for NKT cells. Although alpha-galactosylceramide (alpha-GalCer) loaded B cells can activate NKT cells, it is not well defined whether B cells interfere NKT cell stimulating activity of DCs. Unexpectedly, we found in this study that B cells can promote Th1-skewed NKT cell response, which means a increased level of IFN-gamma by NKT cells, concomitant with a decreased level of IL-4, in the circumstance of co-culture of DCs and B Cells. Remarkably, the response promoted by B cells was dependent on CD1d expression of B cells.
