The Relationship between Brachial Ankle Pulse Wave Velocity and Complement 1 Inhibitor.
10.3346/jkms.2009.24.5.831
- Author:
Yong Min CHAE
1
;
Jong Kwon PARK
Author Information
1. Department of Surgery, Masan Samsung Hospital, Sungkyunkwan University School of Medicine, Masan, Korea. jongkwon.park@gmail.com
- Publication Type:Original Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Complement 1 Inhibitor;
Pulse Wave Velocity;
Stiffness
- MeSH:
Adolescent;
Adult;
Age Factors;
Aged;
Ankle/blood supply;
Ankle Brachial Index;
Blood Flow Velocity/physiology;
Blood Pressure/physiology;
Body Mass Index;
Brachial Artery/*physiology;
Complement C1 Inhibitor Protein/*metabolism;
Elasticity;
Female;
Humans;
Male;
Middle Aged;
Predictive Value of Tests;
Regression Analysis;
Risk Factors;
Sex Factors
- From:Journal of Korean Medical Science
2009;24(5):831-836
- CountryRepublic of Korea
- Language:English
-
Abstract:
Complement 1 (C1) inhibitor is an acute phase protein with anti-inflammatory properties. The aim of the present study was to elucidate the relationship between brachial ankle pulse wave velocity (baPWV), the parameter of arterial stiffness, and C1 inhibitor. One hundred subjects were randomly enrolled in this study. Data about baPWV, age, gender, hypertension, smoking, and body mass index (BMI) were measured. Blood tests for total cholesterol, low density lipoprotein, high density lipoprotein, triglycerides, hemoglobin A1c, erythrocyte sedimentation rate, C-reactive protein, complement 3, and C1 inhibitor were performed. Based on the Pearson correlation, the C1 inhibitor showed a positive relation to the baPWV (P<0.001). Multiple regression analysis revealed the significant predictors of baPWV were not only the conventional risk factors of arteriosclerosis and/or atherosclerosis, such as age (P<0.001), gender (P<0.001), hypertension (P<0.001), and BMI (P=0.006), but also the acute phase protein, C1 inhibitor (P=0.025). In conclusion, C1 inhibitor is associated with arterial stiffness through its association with increased inflammation.
