Antihistamine Pretreatment to Reduce Incidence of Withdrawal Movement After Rocuronium Injection.
10.3346/jkms.2009.24.5.879
- Author:
Ho Jun LEE
1
;
Sung Jin HAN
;
Heezoo KIM
;
Il Ok LEE
;
Myoung Hoon KONG
;
Nan Suk KIM
;
Sang Ho LIM
;
Mi Kyoung LEE
Author Information
1. Department of Anesthesiology and Pain Medicine, Guro Hospital, Korea University College of Medicine, Seoul, Korea. andigi@korea.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Antihistamine;
Pain;
Rocuronium
- MeSH:
Adult;
Androstanols/*administration & dosage/adverse effects;
Anesthetics, Intravenous/administration & dosage;
Double-Blind Method;
Female;
Histamine H1 Antagonists/*pharmacology;
Humans;
Incidence;
Injections, Intravenous;
Male;
Middle Aged;
Movement/drug effects/physiology;
Neuromuscular Nondepolarizing Agents/*administration & dosage/adverse effects;
Pain/chemically induced;
Pain Measurement;
Pheniramine/*pharmacology;
Thiopental/administration & dosage
- From:Journal of Korean Medical Science
2009;24(5):879-882
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study was to determine the effectiveness of antihistamine therapy for withdrawal movements caused by rocuronium injection. One hundred seventy one ASA I-II adults undergoing elective surgery were randomly assigned to one of two groups. Patients in the control group (Group C) were premedicated with 2 mL normal saline, and those in the antihistamine group (Group A) were pre-medicated with 2 mL (45.5 mg) pheniramine maleate. After the administration of thiopental sodium 5 mg/kg, rocuronium 0.6 mg/kg was injected. Withdrawal movements were assessed using a four-grade scale. The administration of antihistamine reveals lower grade of withdrawal movement after rocuronium injection.
