The Effects of Intravenous Ephedrine During Spinal Anesthesia for Cesarean Delivery: A Randomized Controlled Trial.
10.3346/jkms.2009.24.5.883
- Author:
Iclal Ozdemir KOL
1
;
Kenan KAYGUSUZ
;
Sinan GURSOY
;
Ali CETIN
;
Zeki KAHRAMANOGLU
;
Fikret OZKAN
;
Caner MIMAROGLU
Author Information
1. Department of Anesthesiology, Cumhuriyet University School of Medicine, Sivas, Turkey. driclal@gmail.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Anesthesia, Spinal;
Cesarean Section;
Ephedrine;
Hypotension
- MeSH:
Adult;
*Anesthesia, Spinal/adverse effects;
Blood Pressure/drug effects;
*Cesarean Section;
Ephedrine/administration & dosage/*therapeutic use;
Female;
Heart Rate/drug effects;
Humans;
Hypotension/chemically induced/prevention & control;
Injections, Intravenous;
Postoperative Nausea and Vomiting/prevention & control;
Pregnancy;
Vasoconstrictor Agents/administration & dosage/*therapeutic use
- From:Journal of Korean Medical Science
2009;24(5):883-888
- CountryRepublic of Korea
- Language:English
-
Abstract:
We designed a randomized, double-blinded study to determine the efficacy and safety of 0.5 mg/kg intravenous ephedrine for the prevention of hypotension during spinal anesthesia for cesarean delivery. Patients were randomly allocated into two groups: ephedrine group (n=21) and control group (n=21). Intravenous preload of 15 mL/kg lactated Ringer's solution was given. Shortly after the spinal injection, ephedrine 0.5 mg/kg or saline was injected intravenous for 60 sec. The mean of highest and lowest heart rate in the ephedrine group was higher than those of control group (P<0.05). There were significant lower incidences of hypotension and nausea and vomiting in the ephedrine group compared with the control group (8 [38.1%] vs. 18 [85.7%]); (4 [19%] vs. 12 [57.1%], respectively) (P<0.05). The first rescue ephedrine time in the ephedrine group was significantly longer (14.9+/-7.1 min vs. 7.9+/-5.4 min) than that of the control group (P<0.05). Neonatal outcome were similar between the study groups. These findings suggest, the prophylactic bolus dose of 0.5 mg/kg intravenous ephedrine given at the time of intrathecal block after a crystalloid fluid preload, plus rescue boluses reduce the incidence of hypotension.
