Increased Transforming Growth Factor-beta1 in Alcohol Dependence.
10.3346/jkms.2009.24.5.941
- Author:
Yong Ku KIM
1
;
Boung Chul LEE
;
Byung Joo HAM
;
Byung Hwan YANG
;
Sungwon ROH
;
Joonho CHOI
;
Tae Cheon KANG
;
Young Gyu CHAI
;
Ihn Geun CHOI
Author Information
1. Department of Psychiatry, College of Medicine, Korea University, Ansan Hospital, Ansan, Korea.
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Alcohols;
Transforming Growth Factor beta1
- MeSH:
Adult;
Alcoholism/*blood;
Enzyme-Linked Immunosorbent Assay;
Humans;
Liver Diseases/pathology/ultrasonography;
Male;
Middle Aged;
Tomography, X-Ray Computed;
Transforming Growth Factor beta1/*blood
- From:Journal of Korean Medical Science
2009;24(5):941-944
- CountryRepublic of Korea
- Language:English
-
Abstract:
Ethanol and its metabolite acetaldehyde increase transforming growth factor beta1 (TGF-beta1) expression in animal studies. TGF-beta1 is related with the hepatic stellate cell (the key element of hepatic fibrogenesis) and the radial glia (the key element of neuronal migration). Blood samples were collected from 41 patients with alcohol dependence, TGF-beta1 levels measured by ELISA were compared with 41 normal subjects. Plasma TGF-beta1 levels in the patients with alcohol dependence (1,653.11+/-532.45 pg/mL) were significantly higher than those of healthy subjects (669.87+/-366.53 pg/mL) (P=0.000). Patients with or without liver pathology showed no difference in TGF-beta1 (P=0.36). Increased TGF-beta1 may mediate deleterious effect of alcohol such as hepatic fibrosis and suppressed neuronal developments in alcohol dependence patients.
