Esophageal Cancer Initially Presenting as Severe Paraneoplastic Hypercalcemia Requiring Hemodialysis.
10.4166/kjg.2015.65.6.361
- Author:
Hye Shin AHN
1
;
Jong Min YUN
;
Yeong Bok LEE
;
Yu Mi KO
;
Jung Eun LEE
;
Hye Sung WON
;
Sung Soo KIM
;
Young Ok KIM
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. cmckyo@catholic.ac.kr
- Publication Type:Case Reports ; English Abstract
- Keywords:
Hypercalcemia;
Esophageal neoplasms;
Hemodialysis
- MeSH:
Aged;
Calcium/blood;
Carcinoma, Squamous Cell/*diagnosis/pathology;
Endoscopy, Digestive System;
Esophageal Neoplasms/*diagnosis/pathology;
Humans;
Hypercalcemia/*diagnosis/pathology;
Male;
Parathyroid Hormone-Related Protein/blood;
Renal Dialysis;
Severity of Illness Index;
Tomography, X-Ray Computed
- From:The Korean Journal of Gastroenterology
2015;65(6):361-365
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Paraneoplastic hypercalcemia without bone metastasis occurs rarely in esophageal cancer. A 75-year-old man was admitted for general weakness and lethargy. Laboratory data showed high serum calcium level (corrected calcium 14.6 mg/dL), low parathyroid hormone level (3.3 pg/mL) and high parathyroid hormone-related peptide level (3.5 pmol/L). Esophagogastroscopy showed a malignant tumor in the esophagus. Histology showed moderately differentiated squamous cell carcinoma. Bone scan showed no evidence of bone metastasis. Since the patient's calcium levels remained high and mental state did not show improvement despite intravenous fluid therapy, diuretics and intravenous bisphosphonate, hemodialysis was started. After hemodialysis treatment, the serum calcium level subsequently normalized and his mental status improved. Herein, we report a rare case of paraneoplastic hypercalcemia in a patient with esophageal cancer.
