Chronic Graft-Versus-Host Disease Mimicking Psoriasis in a Patient with Hemophagocytic Lymphohistiocytosis.
- Author:
Sihyeok JANG
1
;
In Su KIM
;
Sang Woong YOUN
Author Information
- Publication Type:Case Report
- Keywords: Bone marrow transplantation; Graft-versus-host disease; Hemophagocytic lymphohistiocytosis; Psoriasiform eruption; Psoriasis
- MeSH: Adult; Ambulatory Care Facilities; Biopsy; Bone Marrow Transplantation; Female; Graft vs Host Disease*; Humans; Lymphohistiocytosis, Hemophagocytic*; Phototherapy; Psoriasis*; Siblings; Skin; Vitiligo
- From:Annals of Dermatology 2016;28(1):90-93
- CountryRepublic of Korea
- Language:English
- Abstract: Graft-versus-host disease (GVHD) is a common complication of bone marrow transplantation (BMT) that can be classified as acute or chronic. Chronic GVHD, which usually occurs more than 3 months after BMT, includes typical lichenoid or sclerodermatous lesions. Psoriasiform eruption is a rare clinical manifestation of chronic GVHD, and there have been no reports of psoriasiform chronic GVHD associated with hemophagocytic lymphohistiocytosis. A 33-year-old woman who was diagnosed with hemophagocytic lymphohistiocytosis 10 years ago visited our outpatient clinic with psoriasiform eruption over her entire body. She underwent allogeneic BMT 7 months previously from her sibling. Skin biopsy was performed on the lesion, and the histological features suggested GVHD. The psoriasiform lesions improved with narrow-band ultraviolet B phototherapy, with secondary vitiligo remaining on the corresponding locations.
