Proposal for a Standardized Pathology Report of Gastroenteropancreatic Neuroendocrine Tumors: Prognostic Significance of Pathological Parameters.
- Author:
Mee Yon CHO
1
;
Jin Hee SOHN
;
So Young JIN
;
Hyunki KIM
;
Eun Sun JUNG
;
Mi Jung KIM
;
Kyoung Mee KIM
;
Woo Ho KIM
;
Joon Mee KIM
;
Yun Kyung KANG
;
Joon Hyuk CHOI
;
Dae Young KANG
;
Youn Wha KIM
;
Eun Hee CHOI
Author Information
1. Department of Pathology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicirne, Wonju, Korea.
- Publication Type:Original Article
- Keywords:
Neuroendocrine tumors;
Digestive system;
Pathology;
Staging;
Grading;
Prognosis
- MeSH:
Consensus;
Digestive System;
Humans;
Joints;
Korea;
Lymph Nodes;
Neoplasm Metastasis;
Neuroendocrine Tumors;
Prognosis;
Synaptophysin
- From:Korean Journal of Pathology
2013;47(3):227-237
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: There is confusion in the diagnosis and biological behaviors of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), because of independently proposed nomenclatures and classifications. A standardized form of pathology report is required for the proper management of patients. METHODS: We discussed the proper pathological evaluation of GEP-NET at the consensus conference of the subcommittee meeting for the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. We then verified the prognostic significance of pathological parameters from our previous nationwide collection of pathological data from 28 hospitals in Korea to determine the essential data set for a pathology report. RESULTS: Histological classification, grading (mitosis and/or Ki-67 labeling index), T staging (extent, size), lymph node metastasis, and lymphovascular and perineural invasion were significant prognostic factors and essential for the pathology report of GEP-NET, while immunostaining such as synaptophysin and chromogranin may be optional. Furthermore, the staging system, either that of the 2010 American Joint Cancer Committee (AJCC) or the European Neuroendocrine Tumor Society (ENETS), should be specified, especially for pancreatic neuroendocrine neoplasms. CONCLUSIONS: A standardized pathology report is crucial for the proper management and prediction of prognosis of patients with GEP-NET.
