Immunohistochemical Staining in Metastatic Skin Cancer.
- Author:
Yoo Shin LEE
;
Kwang Hyun CHO
;
Seon Hoon KIM
;
Chul Woo KIM
- Publication Type:Original Article
- Keywords:
Immunohistochemical staining;
Metastatic skin cancer
- MeSH:
Adenocarcinoma;
Carcinoma, Large Cell;
Carcinoma, Papillary;
Carcinoma, Squamous Cell;
Gastrointestinal Tract;
Keratins;
Lung;
Membranes;
Skin Neoplasms*;
Skin*;
Stomach;
Thyroid Gland;
Biomarkers, Tumor
- From:Korean Journal of Dermatology
1987;25(4):427-434
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Immunohistochemial staining was performed in metastatic skin cancer using a variety of antistera. Both carcinoembrytonic antigen(CEA) and epithelial membrane antigen(EMA) were demonstrated in large cell carcinoma of the lung, adenocarcinoma of the stomach and skin adnexal cancer with eccrine differentiation. Although papillary carcinoma of the thyroid, squamous cell carcinoma of the skin and squamous cell carcinoma of the lung showed positive staining for CEA and EMA, these were weak or focal reactions in the keratinizing area. In rectal adenocarcinoma, staining for CEA was significantly positive, but staining for EMA was negative. Epiderrnal cytokeratin was observed in squamous cell carcinoma of the lung, squamous cell carcinoma of the skin and skin adnexal cancer with eccrine differentiation. Epidermal cytokeratin was also demonstrated in well differentiated adenocarcinoma of the gastrointestinal tract. By using a variety of tumor markers, the authors tried to locate possible primary sites in six metastatic skin cancers of unknown origin.
