Outcome and Current Status of Therapeutic Hypothermia Following Out-of-hospital Cardiac Arrest in Korea from the Korea Hypothermia Network Registry.
- Author:
Byung Kook LEE
1
;
Kyu Nam PARK
;
Gu Hyun KANG
;
Kyung Hwan KIM
;
Giwoon KIM
;
Won Young KIM
;
Jin Hong MIN
;
Yooseok PARK
;
Jung Bae PARK
;
Gil Joon SUH
;
Yoo Dong SON
;
Jonghwan SHIN
;
Joo Suk OH
;
Yeon Ho YOU
;
Dong Hoon LEE
;
Jong Seok LEE
;
Hoon LIM
;
Tae Chang JANG
;
Gyu Chong CHO
;
In Soo CHO
;
Kyoung Chul CHA
;
Seung Pill CHOI
;
Wook Jin CHOI
;
Chul HAN
Author Information
1. Department of Emergency Medicine, School of Medicine, Chonnam National University, Gwangju, Korea.
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Out-of-hospital cardiac arrest;
Induced hypothermia;
Registries
- MeSH:
Adult;
Brain;
Coma;
Coronary Angiography;
Hospital Mortality;
Humans;
Hyperglycemia;
Hypothermia*;
Hypothermia, Induced;
Korea;
Out-of-Hospital Cardiac Arrest*;
Registries;
Republic of Korea;
Rewarming;
Survivors
- From:Journal of the Korean Society of Emergency Medicine
2014;25(6):747-755
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Therapeutic hypothermia (TH) has become a standard strategy for reducing brain damage in the postresuscitation period. The aim of this study is to investigate the outcomes and current performance of TH with out-of-hospital cardiac arrest (OHCA) survivors through the Korean hypothermia network (KORHN) registry. METHODS: We used the KORHN registry, a web-based, multicenter registry that includes 24 participating hospitals throughout the Republic of Korea. Adult comatose OHCA survivors treated with TH from 2007 to 2012 were included. The primary outcomes were neurologic outcome at hospital discharge and in-hospital mortality. The secondary outcomes were TH performance and adverse events during TH. RESULTS: A total of 930 patients were included; of these, 556 (59.8%) patients survived to discharge and 249 (26.8%) were discharged with good neurologic outcomes. The median time from return of spontaneous circulation (ROSC) to the start of TH was 101 (interquartile range (IQR): 46-200) minutes. The induction, maintenance, and rewarming durations were 150 (IQR: 80-267) minutes, 1440 (IQR: 1290-1440) minutes, and 708 (IQR: 420-900) minutes, respectively. The time from the ROSC to coronary angiography was 1,045 (IQR: 121-12,051) hours. Hyperglycemia (46.3%) was the most frequent adverse event. CONCLUSION: Over one quarter of OHCA survivors (26.8%) were discharged with good neurologic outcome. TH performance was managed appropriately in terms of the factors related to the timing of TH, which were the start time for cooling and the rewarming duration.
