The Experience and Management of Two Cases of Metformin-associated Lactic Acidosis.
- Author:
Hyeuk Soo LEE
1
;
Choong Sil SEONG
;
Byung Sun KIM
;
Woong Ki LEE
;
Hye Mi CHOI
;
Hyun Ju YOON
;
Jeong Gwan KIM
;
In O SUN
;
Kwang Young LEE
Author Information
1. Division of Nephrology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea. kwangpmc@daum.net
- Publication Type:Case Report
- Keywords:
Metformin;
Acidosis;
Lactic;
Renal replacement therapy
- MeSH:
Acidosis;
Acidosis, Lactic*;
Diabetes Mellitus, Type 2;
Heart Failure;
Humans;
Korea;
Metformin;
Mortality;
Renal Dialysis;
Renal Insufficiency;
Renal Replacement Therapy
- From:Journal of the Korean Society of Emergency Medicine
2014;25(6):771-774
- CountryRepublic of Korea
- Language:English
-
Abstract:
Metformin, a dimethylbiguanide, is an oral antihyperglycemic drug used in treatment of type 2 diabetes mellitus. It has been reported that metformin may be associated with lactic acidosis in patients with clinical conditions such as renal failure and heart failure. Metformin-associated lactic acidosis (MALA) is a rare, but serious complication with a mortality rate of approximately 30~50%. Therefore, an aggressive treatment strategy including hemodialysis is recommended for these patients. Although continuous renal replacement therapy (CRRT) has been administered in hemodynamically unstable patients with MALA, there are few case reports describing the use of CRRT as a therapeutic modality in Korea. Here, we describe the case histories of two MALA patients who underwent treatment with CRRT.
