Neuronal Hyperexcitability Mediates Below-Level Central Neuropathic Pain after Spinal Cord Injury in Rats.
10.5625/lar.2010.26.3.225
- Author:
Eun Sung PARK
1
;
Younghoon JEON
;
Dae Chul CHO
;
Dong Ho YOUN
;
Young Seob GWAK
Author Information
1. Koatech Co., Pyeongtaek, Korea.
- Publication Type:Review
- Keywords:
Central neuropathic pain;
hyperexcitability;
rat model
- MeSH:
Animals;
Central Nervous System Sensitization;
Discrimination (Psychology);
Neuralgia;
Neurons;
Posterior Horn Cells;
Rats;
Spinal Cord;
Spinal Cord Injuries
- From:Laboratory Animal Research
2010;26(3):225-232
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Spinal cord injury often leads to central neuropathic pain syndromes, such as allodynic and hyperalgesic behaviors. Electrophysiologically, spinal dorsal horn neurons show enhanced activity to non-noxious and noxious stimuli as well as increased spontaneous activity following spinal cord injury, which often called hyperexcitability or central sensitization. Under hyperexcitable states, spinal neurons lose their ability of discrimination and encoding somatosensory information followed by abnormal somatosensory recognition to non-noxious and noxious stimuli. In the present review, we summarize a variety of pathophysiological mechanisms of neuronal hyperexcitability for treating or preventing central neuropathic pain syndrome following spinal cord injury.
