A Case of Pyoderma Gangrenosum Treated by Combination Therapy with Oral Cyclosporin and Platelet Rich Plasma.
- Author:
Min Chul KANG
1
;
Sung Ae KIM
;
Kyu Suk LEE
;
Jae We CHO
Author Information
1. Department of Dermatology, School of Medicine, Keimyung University, Daegu, Korea. janylove99@dsmc.or.kr
- Publication Type:Case Report
- Keywords:
Cyclosporin;
Platelet rich plasma;
Pyoderma gangrenosum
- MeSH:
Female;
Humans
- From:Korean Journal of Dermatology
2010;48(4):313-317
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pyoderma gangrenosum is an uncommon, chronic, neutrophilic ulcerative condition of uncertain pathophysiology. Although the main therapy is the systemic administration of high doses of steroid therapy, many other therapeutic modalities have been widely used. Combination therapy with systemic corticosteroids and cyclosporin has proven effective in many cases. However, prolonged therapy is associated with significant side effects. Platelet rich plasma (PRP) has many growth factors such as PDGF (platelet derived growth factor), VEGF (Vascular endothelial growth factor) and FGF (fibroblast growth factor). Recently, PRP has been gaining attention in the treatment of recalcitrant cutaneous ulcers. An 82-year-old woman presented with recurrent painful ulcers on the dorsal surface of both hands. She had been treated with systemic steroids, cyclosporine, minocylclin, triamcinolone intradermal injection and PRP. Thus, we report a case of pyoderma gangrenosum that was successfully treated with combination therapy of oral cyclosporine and PRP.
