The Standardization of Electroretinogram C-wave in Pigmented Rabbits.
- Author:
Young Soo JO
1
;
Si Yeol KIM
Author Information
1. Department of Ophthalmology, School of Medicine, Kyungpook National University, Taegu, Korea.
- Publication Type:Original Article
- MeSH:
Dark Adaptation;
Rabbits*;
Retinaldehyde
- From:Journal of the Korean Ophthalmological Society
1987;28(2):363-369
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The electroretinogram c-wave is known as a good electrophysiologic test of retinal pigment epithelial function, but its large inter and intra individual variation prevented clinical and experimental application. We recorded a stable c-wave in pigmented rabbits and the following result was obtained. Under dark adaptation state the c-wave amplitude reached equilibrium after 60 minutes, but its interindividal variation was large. The similar c-wave amplitude of right and left eye indicates that contralateral eye can be used as a control during local administration of drugs. The interindividual variation of c-wave amplitude under dim light is much smaller than under dark adaptation. This may be a good indicator in pharmacologic experiment of systemically administered drugs.
