Antihypertensive Effects of Ketanserin in Patients Aging Over 55 with Essential Hypertension.
10.4070/kcj.1991.21.3.614
- Author:
Taek Jong HONG
;
Nam Sik CHUNG
;
Won Heum SHIM
;
Seung Yun CHO
;
Sung Soon KIM
;
Woong Ku LEE
- Publication Type:Original Article
- MeSH:
Aging*;
Blood Pressure;
Diastole;
Heart Rate;
Humans;
Hypertension*;
Ketanserin*;
Serotonin;
Sleep Stages;
Systole
- From:Korean Circulation Journal
1991;21(3):614-619
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To evaluate the antihypertensive effects of serotonin antagonist, ketanserin, a daily dosage of 10~40mg (18.9+/-6.8 mean+/-SE) was administered to 22 patients with essential hypertension and aged 55??1 years (64+/-7.7 mean+/-SE) for 12 weeks. After 12 weeks of ketanserin treatment mean blood pressure decreased from 177.9+/-11.9 to 15.7+/-15.3mmHg in systole and from 104.2+/-7.4 to 88.4+/-7.9mmHg in diastole (P<0.001). There was no significant change in heart rates with ketanserin treatment. The antihypertensive treatment with ketanserin was effective in 18 patients(81.8%) and ineffective in 4 patients (18.2%). Adverse reactions such as drowsiness (8.7%), edama (4.3%) and weakness (4.3%) were noted, but all were mild and transient. This results suggest that ketanserin is an effective and safe antihypersive agent in the treatment of essential hyperension.
