A Clinical Study on the Hypotensive Effect of Lisinopril.
10.4070/kcj.1991.21.3.657
- Author:
Jung Chaee KANG
;
Jeong Gwan CHO
;
Keal Woo CHO
;
Gee Woon LEE
;
Yong Whan CHUNG
;
Jeong Chun PARK
- Publication Type:Original Article
- MeSH:
Adult;
Antihypertensive Agents;
Blood Pressure;
Chemistry;
Cough;
Humans;
Hypertension;
Lisinopril*;
Mouth;
Peptidyl-Dipeptidase A
- From:Korean Circulation Journal
1991;21(3):657-664
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In order to evaluate the hypotensive effect of the lisinopril, a long acting angiotensin converting enzyme inhibitor, 10 to 30mg of lisinopril were administered in 35 hypertensive Korean adults during six weeks after a week observation for washout with stepwise increments of the dose according to the response of the patients blood pressure in every two weeks. The results were ; 1) The supine blood pressures were decreased from 163.7+/-16.6/99.8+/-9.3mmHg to 140.7+/-15.5/87.4+/-9.9mmHg at the end of six weeks' drug therapy(p<0.001). The standing blood pressures were also decreased conferrably and to the some lower levels. 2) In 14 patients to whom the drug was administered longer period(12 to 28 weeks) the blood pressure lowering effects were maintained at the level of that of 6th week. 3) Hematologic examination and blood chemistry revealed no discernible abnormal findings before and after the treatment. 4) In those patients who showed no adequate blood pressure control with other classes of antihypertensive drugs the lisinopril was effective in lowering their blood pressures by adding small doses. 5) During the period of the study a few probably drug-related symptoms developed but not troublesome except dry cough and dry mouth shich forced to stop administering the drug after completion of six weeks' period in one patients. From above results we concluded that lisnopril is effective and safe for the treatment of hypertension in Korean adults.
