A Case Report of Intractable Scleritis Effectively Treated with Infliximab.
10.3341/jkos.2008.49.10.1690
- Author:
Dong Hyun KIM
1
;
Won Ryng WEE
;
Jin Hak LEE
;
Mee Kum KIM
Author Information
1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. kmk9@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Infliximab;
Scleritis;
TNF-a
- MeSH:
Aged;
Anti-Bacterial Agents;
Antibodies, Monoclonal;
Eye;
Humans;
Immunosuppressive Agents;
Orbit;
Orbital Cellulitis;
Sclera;
Scleritis;
Infliximab
- From:Journal of the Korean Ophthalmological Society
2008;49(10):1690-1695
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report a case of a patient with intractable scleritis with conventional immunosuppressive therapy who showed effective treatment with infliximab. CASE SUMMARY: A 71-year-old man presented with orbital cellulitis and diffuse anterior scleritis of his left eye. Although orbital cellulites showed remission with topical and systemic antibiotics, scleritis persisted despite a combination therapy of immunosuppressive agents (cyclosporin, mycophenolate, prednisolone) for 1 month. Finally, he was given infliximab (5 mg/kg) intravenously three times at 2-week intervals, after which ocular pain, chemosis, conjunctival injection, and sclera thickening considerably reduced, and scleritis completely remitted. CONCLUSIONS: The administration of Infliximab seems to be an effective therapy in patients with intractable scleritis undergoing conventional therapy.
