A Study of the Effects of Systemic Heparin and Intrathecal Urokinase on Experimental Cerebral Vasospasm.
- Author:
Yaun Kwan PARK
1
;
Yang Gu CHUNG
;
Hun Gab LEE
;
Ki Chan LEE
;
Jung Wha CHU
Author Information
1. Department of Neurosurgery, College of Medicine, Korea University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Vasospasm;
Systemic heparin;
Intrathecal urokinase;
Arteriography;
TEM
- MeSH:
Adult;
Angiography;
Animals;
Arteries;
Basilar Artery;
Dogs;
Heparin*;
Humans;
Muscle, Smooth;
Necrosis;
Urokinase-Type Plasminogen Activator*;
Vasospasm, Intracranial*
- From:Journal of Korean Neurosurgical Society
1989;18(6):817-826
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The author has investigated the protective effects of systemic Heparin and intrathecal Urokinase in the multi-hemorrhage canine model of severe chronic cerebral vasospasm. Each of 20 adult mongrel dogs was assigned to one of three experimental groups. All animals received a total of 12ml of fresh unheparinized autologous blood via three cisternal injections. Selective vertebral angiograms were obtained before and 8 days after the initial subarachnoid blood injection. Seven animals were treated by systemic Heparin for 7 days, the other seven were treated by intracisternal Urokinase for 3 days, and the remaining were not treated. Comparisons were based on the percentage of reduction in basilar artery diameter(% RBAD). The ultrastructural changes were studied by transmission electron microscopy(TEM). There was a mean reduction(+/-standard deviation) of 65+/-7% in control dogs, 53+/-5% in dogs with systemic Heparin(difference significant t-test, p<0.01), 37+/-6% in dogs with intrathecal Urokinase(difference signignificant, t-test, p<0.01). The preventive effects of intrathecal Urokinase was superior to systemic Heparin. There was a stroung trend toward reduction of medial necrosis in the basilar artery in dogs with intrathecal Urokinase(p<0.01), and with systemic Heparin(0.05
