The Study on Vascular Reactivity to Vasoactive Agents in Isolated Porcine Cerebral Artery.
- Author:
Jong Sea KIM
1
;
Dong Soo PARK
;
Jong Moon KIM
Author Information
1. Department of Neurosurgery, School of Medicine, Wonkwang University, Iksan, Korea.
- Publication Type:In Vitro ; Original Article
- Keywords:
Cerebral arterial spasm;
Porcine internal carotid artery;
Norepinephrine;
Epinephrine;
Serotonin
- MeSH:
Adrenergic Agents;
Carotid Artery, Internal;
Cerebral Arteries*;
Epinephrine;
Negotiating;
Norepinephrine;
Serotonin;
Spasm;
Vasoconstriction;
Vasodilation
- From:Journal of Korean Neurosurgical Society
1989;18(6):827-835
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The present in vitro experiments were performed to investigate the contractile activity and action sites of various vasoactive agents on isolated porcine internal carotid artery as a preliminary study on cerebral arterial spasm. The cumulative dose-response curves were obtained for most vasoactive agents such as serotonin and adrenergic drugs including agonists and these effects were investigated under antagonists in isolated arterial rings. The results of this study suggest that serotonin is the most potent agent for the cerebral arterial spasm, and there are alpha-adrenoceptor and serotonin receptor mediating vasoconstriction and beta-adrenoceptors mediating vasodilation in porcine internal carotid artery. The cross reactivity between alpha-adrenoceptor and serotonin receptor suggests that the two types of receptors have common features which will be further investigated.
