Isolated adrenocorticotropic hormone deficiency associated with empty sella syndrome.
- Author:
Jun Ho CHOI
1
;
Byoung Hyun PARK
;
Chung Gu JO
Author Information
1. Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea. parkbhmd@wonkwang.ac.kr
- Publication Type:Case Report
- Keywords:
Empty sella syndrome;
Isolated ACTH deficiency
- MeSH:
Adrenal Insufficiency;
Adrenocorticotropic Hormone;
Empty Sella Syndrome;
Female;
Follow-Up Studies;
Growth Hormone;
Humans;
Hydrocortisone;
Hypoglycemia;
Insulin-Like Growth Factor I;
Magnetic Resonance Imaging;
Plasma;
Prednisolone;
Sella Turcica
- From:Korean Journal of Medicine
2008;75(5):597-601
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Isolated adrenocorticotropic hormone (ACTH) deficiency is an uncommon disorder for which the pathogenetic mechanism has not yet been identified. It has been reported that isolated ACTH deficiency (ICD) may be accompanied by deficiencies in other pituitary hormones; impaired growth hormone (GH) secretion was noted in 20 to 30% of ICD patients. Here, we describe a female patient with isolated ACTH deficiency accompanied by empty sella syndrome presenting as hypoglycemia, which was confirmed via various endocrine tests and magnetic resonance imaging (MRI) of the sella turcica. The patient's symptoms improved rapidly with prednisolone therapy and, during follow-up, her previously impaired GH response to provocative stimuli and high TSH levels were corrected by glucocorticoid replacement alone. However, treatment failed to normalize plasma IGF-1 levels, suggesting that physiological cortisol levels are necessary for a normal plasma GH response to provocative stimuli.
