Ipsilateral Cerebral and Contralateral Cerebellar Hyperperfusion in Patients with Unilateral Cerebral Infarction; SPM Analysis.
- Author:
Sun Pyo HONG
1
;
Joon Kee YOON
;
Bong Hoi CHOI
;
In Soo JOO
;
Seok Nam YOON
Author Information
1. Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, Suwon, Korea. jkyoon3@empal.com
- Publication Type:Original Article
- Keywords:
(99m)Tc-ECD perfusion SPECT;
cerebral infarction;
statistical parametric mapping;
functional recovery
- MeSH:
Cerebral Cortex;
Cerebral Infarction;
Humans;
Infarction;
Perfusion;
Retrospective Studies;
Stroke;
Tomography, Emission-Computed, Single-Photon
- From:Nuclear Medicine and Molecular Imaging
2008;42(5):347-353
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Cortical reorganization has an important role in the recovery of stroke. We analyzed the compensatory cerebral and cerebellar perfusion change in patients with unilateral cerebral infarction using statistical parametric mapping (SPM). MATERIALS AND METHODS: Fifty seven (99m)Tc-Ethylene Cystein Diethylester (ECD) cerebral perfusion SPECT images of 57 patients (male/female=38/19, mean age=56+/-17 years) with unilateral cerebral infarction were evaluated retrospectively. Patients were divided into subgroups according to the location (left, right) and the onset (acute, chronic) of infarction. Each subgroup was compared with normal controls (male/female=11/1, mean age=36+/-10 years) in a voxel-by-voxel manner (two sample t-test, p<0.001) using SPM. RESULTS: All 4 subgroups showed hyperperfusion in the ipsilateral cerebral cortex, but not in the contralateral cerebral cortex. Chronic left and right infarction groups revealed hyperperfusion in the ipsilateral primary sensorimotor cortex, meanwhile, acute subgroups did not. Contralateral cerebellar hyperperfusion was also demonstrated in the chronic left infarction group. CONCLUSION: Using (99m)Tc-ECD SPECT, we observed ipsilateral cerebral and contralateral cerebeller hyperperfusion in patients with cerebral infarction. However, whether these findings are related to the recovery of cerebral functions should be further evaluated.
