Usefulness of F-18 FDG PET/CT in Staging of Peripheral T Cell Lymphoma.
- Author:
Yun Hee KANG
1
;
Seok Tae LIM
;
Dong Wook KIM
;
Hwan Jeong JEONG
;
Myung Hee SOHN
;
Chang Yeol YIM
Author Information
1. Department of Nuclear Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk, Korea. mhsohn@chonbuk.ac.kr
- Publication Type:Original Article
- Keywords:
PET/CT;
peripheral T cell lymphoma;
F-18 FDG
- MeSH:
Humans;
Lymphoma;
Lymphoma, Non-Hodgkin;
Lymphoma, T-Cell;
Lymphoma, T-Cell, Cutaneous;
Lymphoma, T-Cell, Peripheral;
Sensitivity and Specificity;
Skin
- From:Nuclear Medicine and Molecular Imaging
2008;42(5):369-374
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: F-18 FDG PET/CT has excellent sensitivity and specificity for staging non-Hodgkin lymphomas, but to the author's knowledge few studies to date have evaluated FDG PET/CT in peripheral T cell lymphoma. We evaluated the usefulness of F-18 FDG PET/CT in staging of patients with peripheral T cell lymphoma, especially indolent cutaneous T cell lymphomas. MATERIALS AND METHODS: Twenty five patients (M:F=17:8, age 53.7+/-14.8 yrs) with biopsy-proven indolent cutaneous T cell (CL) or noncutaneous T cell lymphomas (NCL) underwent PET/CT scans for staging at baseline. Peak standardized uptake values (p-SUV) of all abnormal foci were measured and compared between cutaneous and noncutaneous lesions. F-18 FDG PET/CT was performed on 6 patients with indolent CL and on 19 patients with NCL. RESULTS: All 6 patients with indolent CL had no significant FDG avidity in the skin despite histologically positive cutaneous lesions. However, FDG avidity appeared in extracutaneous lesions (lymph nodes) in two patients with CL where CT imaging suggested lymphoma involvement (mean p-SUV 4.26+/-0.37 in noncutaneous lesions in CL). In NCL, FDG avidity was demonstrated in all lesions where CT imaging suggested lymphoma involvement (mean p-SUV, 8.52+/-5.00 in noncutaneous lesions in NCL). CONCLUSION: F-18 FDG PET/CT has the limitation of usefulness for the evaluation of the skin in indolent CL. In contrast, F-18 FDG PET/CT is sensitive in staging evaluation of extracutaneous lesions regardless of CL or NCL.
