Coagulation Factor Abnormality of Deep Vein Thrombosis in Korea.
- Author:
Dong Ik KIM
1
;
Seung HUH
;
Hang Seok CHANG
;
Tae Sung LEE
;
Jun Bong CHANG
;
Jin Hyun JOH
;
Yong Il KIM
;
Byung Boong LEE
Author Information
1. Division of Vascular Surgery, Samsung Medical Center, Sung Kyun Kwan University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Thrombosis;
Venous;
Coagulation;
Protein C;
Protein S;
Antithrombin III
- MeSH:
Antithrombin III;
Antithrombin III Deficiency;
Blood Coagulation Factors*;
Causality;
Collagen Diseases;
Female;
Heparin;
Humans;
Iliac Vein;
Immobilization;
International Normalized Ratio;
Korea*;
Leg;
Lower Extremity;
Male;
Mesenteric Veins;
Plasminogen;
Portal Vein;
Protein C;
Protein C Deficiency;
Protein S;
Protein S Deficiency;
Pulmonary Embolism;
Research Personnel;
Thromboplastin;
Thrombosis;
Veins;
Vena Cava, Inferior;
Venous Thrombosis*;
Warfarin
- From:Journal of the Korean Surgical Society
1998;54(5):738-742
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A deep vein thrombosis(DVT) is responsible for a number of significant medical problems including pulmonary embolisms. The factors that cause DVT have been studied by many investigators. The cases of 31 DVT patients, 19 males and 12 females, who were treated from January 1994 through January 1996, were reviewed. The mean age was 47.3 15.9 years. Four cases(12.9%) affected the right leg, 25 cases(80.6%) on the left leg, and 2 cases(6.5%) the portal vein and the mesenteric vein. Among the 29 lower extremity DVT cases, 16 cases(51.6%) showed ipsilateral iliac vein thromboses and 1 case(3.2%) showed an inferior vena cava thrombosis. Five cases(16.1%) had a history of an explo-laparotomy, 2 cases(6.5%) had a history of immobilization, 1 case(3.2%) had a history of trauma to the involved leg, and 2 cases(6.5%) had a history of collagen disease. However, 21 cases(67.7%) had no history of any predisposing factors. Five cases(16.1%) were confirmed as protein C deficiency, 3 cases(9.7%) as protein S deficiency, 4 cases(12.9%) as antithrombin III deficiency, 3 cases(9.7%) as plasminogen deficiency, and 6 cases(19.4%) as -2 antiplasmin deficiency. Ten(32.3%) of the 31 cases had multiple coagulation factor deficiency. Three patients(9.7%) had been inserted with Greenfield filter into the inferior vena cava. Initially, unfractionated heparin was injected intravenously under the control of the activated partial thromboplastin time(aPTT) until the warfarin effect reached INR 1.75~2.0. Only 5 of the 31 cases agreed to a family to study to detect any possible coagulation factor abnormality. Three of these 5 families showed coagulation factor abnormality. Our results show that more extensive study on DVT is needed in the Korean population.
