Expression of claudin-1, beta-catenin and E-cadherin in adenocarcinoma of the colon.
- Author:
Eun Jung CHA
1
;
Kyu Yun JANG
;
Ha Na CHOI
;
Kyung Ryul KIM
;
Keum Ha CHOI
;
Sung Ho HWANG
;
Woo Sung MOON
;
Myoung Jae KANG
;
Dong Geun LEE
Author Information
1. Department of Pathology, Chonbuk National University Medical School, Institute for Medical Sciences and Center for Healthcare Technology Development, Jeonju, Korea. kyjang@chonbuk.ac.kr
- Publication Type:Original Article
- Keywords:
Colon;
Adenocarcinoma;
Claudin 1;
beta Catenin;
E-cadherins
- MeSH:
Adenocarcinoma;
beta Catenin;
Cadherins;
Claudin-1;
Colon;
Lymph Nodes;
Neoplasm Metastasis;
Proteins
- From:Korean Journal of Medicine
2008;74(2):146-153
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Disruption of the cell-to-cell junction with changes in the expression of the junctional proteins is the hallmark of cancer invasion and metastasis. To investigate the roles of claudin-1, beta-catenin and E-cadherin in adenocarcinoma of the colon, the relationship of their expression with clinical and pathological factors were examined. METHODS: The expression of claudin-1, beta-catenin and E-cadherin were examined in 47 cases of adenocarcinoma of the colon by immunohistochemical staining. RESULTS: A reduced claudin-1 expression was associated with advanced lymph node metastasis (p=0.019) and histological dedifferentiation at the invasive front (p=0.030). A reduced expression of beta-catenin and E-cadherin were correlated with histological dedifferentiation (p=0.012, p=0.010, respectively). The reduced expression of two or more proteins was correlated with the histological findings of dedifferentiation (p=0.030). CONCLUSIONS: These results suggest that loss of claudin-1, beta-catenin and E-cadherin expression may be correlated with the progression of adenocarcinoma of the colon and associated with an advanced histological grade.
